Relationship Between the Gut Microbiota and Alzheimer’s Disease: A Systematic Review
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Gómez del Pulgar García-Madrid, MercedesFecha de publicación:
2022-05-17Resumen:
Background:In recent years, scientific research on the gut microbiota and their relationship with some diseases, including neurological ones, has notably increased. As a result of these investigations, the so-called gut-brain axis arises. Despite its influence on the evolution and development of cognitive impairment, the gut-brain axis is little defined and demonstrated. Objective:To provide the best scientific evidence available on the relationship between the gut microbiota and Alzheimer’s disease. Method:Systematic and narrative review of the information generated in the last 5 years in national and international databases, in English and Spanish. Results:Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review. Conclusion:The results of these studies support the hypothesis that there is a relationship between the gut microbiota and cognitive disorders through the gut-brain axis. However, today, there is a substantial lack of human studies, especially clinical trials, which makes it difficult to formulate clinical recommendations on this topic.
Background:In recent years, scientific research on the gut microbiota and their relationship with some diseases, including neurological ones, has notably increased. As a result of these investigations, the so-called gut-brain axis arises. Despite its influence on the evolution and development of cognitive impairment, the gut-brain axis is little defined and demonstrated. Objective:To provide the best scientific evidence available on the relationship between the gut microbiota and Alzheimer’s disease. Method:Systematic and narrative review of the information generated in the last 5 years in national and international databases, in English and Spanish. Results:Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review. Conclusion:The results of these studies support the hypothesis that there is a relationship between the gut microbiota and cognitive disorders through the gut-brain axis. However, today, there is a substantial lack of human studies, especially clinical trials, which makes it difficult to formulate clinical recommendations on this topic.
Palabra(s) clave:
Alzheimer’s disease
gut-brain axis
gut microbiome
microbiota
Parkinson’s disease
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