The relationship between Parkinson’s disease and sexual hyperactivity secondary to drug treatment: A systematic review

Abstract

Introduction:This review addresses the prevalence of hypersexual behavior in Parkinson’s patients and the underlying neurobiological mechanisms, identifying risk and protective factors, comparing incidence among different treatments, and proposing recommendations for management and prevention. Objective:To conduct a review on the relationship between Parkinson’s disease and hypersexual behavior as a result of pharmacological treatment. Methodology:The search strategy, guided by PRISMA and PICOS criteria, focuses on the correlation between Parkinson’s disease and hypersexual behavior due to pharmacological treatment. Utilizing databases like PubMed and Proquest, studies from the last 10 years in English or Spanish were selected, emphasizing clinical trials with Parkinson’s patients under treatment. Inaccessible, irrelevant, or mixed-sample studies were excluded. The Cochrane Scale assessed the risk of bias. Results:Out of 122 records, 103 remained after eliminating duplicates; 48 were reviewed, and ultimately, 6 studies met the inclusion criteria for analysis. Conclusions:Synthesizing the risk and protective factors linked to hypersexual behavior in Parkinson’s patients receiving pharmacological treatment underscores the critical need for early detection and incorporation of these factors into clinical care. The suggested guidelines for managing and preventing hypersexual behavior in these patients carry substantial practical implications.